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Use of Amniotic Membrane Transplantation in Treatment of Venous Leg Ulcers

Amniotic membrane (AM), the most internal placental membrane, has unique properties including antiadhesive effects, bacteriostatic, wound protection and pain-reduction properties, as well as epithelialization initialization capacities.  Furthermore, AM is widely available and less costly than other bioengineered skin substitutes. In a prospective pilot study, we evaluated the safety, feasibility, and the effects on healing of AM graft in 15 patients with chronic venous leg ulcers. AM grafts were prepared from placentas harvested during cesarean section.  All grafted AM had adhered to the wound bed 7 days after being applied  with a 100% engraftment rate. The percentage of granulation tissue increased significantly (from 17% on day 0 to 69% on day 14, p < 0.0001), along with a significant decrease of fibrinous slough (from 36% at day 0 to 16% at day 14,p < 0.001).  Read more…

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